Cajun Chicken Alfredo Fettuccine

Featured in: Creamy Comfort Meals

This dish brings together tender chicken breasts seasoned with bold Cajun spices and perfectly cooked fettuccine pasta, enveloped in a rich, creamy Velveeta and Parmesan cheese sauce. Garlic and butter add depth, while cayenne offers optional heat. The sauce's smooth texture complements the spicy chicken, creating a comforting and flavorful Southern-inspired plate. Fresh parsley garnish adds brightness, making this an approachable and satisfying meal for any occasion.

Updated on Sun, 23 Nov 2025 16:53:00 GMT
Tender Cajun chicken Alfredo fettuccine pasta, a comforting, creamy Velveeta-based dish ready to serve. Save
Tender Cajun chicken Alfredo fettuccine pasta, a comforting, creamy Velveeta-based dish ready to serve. | amberladle.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This dish is one of my go-to meals when I want something comforting yet full of bold flavors that impress every time.

Ingredients

  • Chicken: 2 large boneless, skinless chicken breasts 1 ½ tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter 2 cloves garlic, minced 1 cup (240 ml) heavy cream 8 oz (225 g) Velveeta cheese, cubed ½ cup (50 g) grated Parmesan cheese ½ teaspoon black pepper ¼ teaspoon cayenne pepper (optional, for extra heat) Salt, to taste
  • Garnish: 2 tablespoons fresh parsley, chopped Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside, reserving ½ cup pasta water.
Step 2:
While the pasta cooks, pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet, heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side, or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken, let rest 5 minutes, then slice thinly.
Step 4:
In the same skillet, reduce heat to medium. Add butter and garlic; sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring often until melted and smooth.
Step 6:
Add Parmesan cheese, black pepper, and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick, add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
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| amberladle.com

This recipe always brings my family to the table eager to share stories and laughter over a delicious meal.

Required Tools

Large pot, large skillet, knife and cutting board, tongs or pasta fork, measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta, Parmesan, cream, butter), wheat (fettuccine), and chicken. Those with allergies should check ingredient labels for hidden allergens.

Nutritional Information

Per serving: 670 calories, 32 g total fat, 57 g carbohydrates, 41 g protein

Delicious fettuccine pasta smothered in spicy, cheesy Cajun Chicken Alfredo with vibrant parsley garnish. Save
Delicious fettuccine pasta smothered in spicy, cheesy Cajun Chicken Alfredo with vibrant parsley garnish. | amberladle.com

This Cajun Chicken Alfredo is a perfect balance of creamy and spicy that will quickly become a family favorite.

Recipe FAQs

How can I adjust the spiciness of the dish?

Modify the amount of Cajun seasoning and cayenne pepper to suit your heat preference; omit cayenne for milder flavor.

What type of pasta works best?

Fettuccine is ideal to hold the creamy sauce, but other long, flat pastas like linguine can be used as well.

Can I prepare the chicken in advance?

Yes, cooking and slicing the chicken ahead saves time; reheat gently in sauce before serving.

How do I prevent the sauce from becoming too thick?

Reserve some pasta water and add it gradually to the sauce until desired consistency is achieved.

What are some good side dishes to pair with this meal?

Light green salads and crisp white wines like Chardonnay complement the rich flavors well.

Cajun Chicken Alfredo Fettuccine

Tender Cajun chicken and creamy Velveeta sauce combine with fettuccine for a rich, comforting Southern-style meal.

Prep time
15 min
Cook time
25 min
Overall time
40 min
Created by Rachel Hayes


Skill required Easy

Cuisine American (Cajun-inspired)

Makes 4 Serving size

Diet preferences None specified

What you need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 ounces Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

How to make it

Step 01

Cook Pasta: Bring a large pot of salted water to a boil. Cook fettuccine according to package instructions until al dente. Drain, reserving ½ cup pasta water, and set pasta aside.

Step 02

Prepare Chicken: Pat chicken breasts dry and rub both sides evenly with Cajun seasoning.

Step 03

Sear Chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken and cook for 5 to 6 minutes per side until golden brown and internal temperature reaches 165°F. Remove chicken, let rest for 5 minutes, then slice thinly.

Step 04

Sauté Garlic: Reduce skillet heat to medium. Add butter and garlic, sautéing for 1 minute until fragrant.

Step 05

Prepare Sauce: Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring frequently until completely melted and smooth.

Step 06

Season Sauce: Incorporate Parmesan cheese, black pepper, and cayenne pepper if using. Mix until fully combined and creamy. Adjust thickness by adding reserved pasta water gradually as needed.

Step 07

Combine Pasta and Sauce: Toss cooked fettuccine in the sauce until evenly coated.

Step 08

Plate and Garnish: Divide pasta among plates, top with sliced Cajun chicken, and garnish with chopped parsley and additional Parmesan if desired.

Equipment needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy info

Always review ingredients for allergens. Talk to your healthcare provider if you're unsure.
  • Contains milk/dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine)
  • Contains poultry (chicken)

Nutrition details (each serving)

Nutritional details are for reference and aren't a substitute for healthcare guidance.
  • Calorie Count: 670
  • Fat content: 32 g
  • Carbohydrate: 57 g
  • Protein amount: 41 g